Radioprotective Effect of Chitosan in Sub-lethally X-ray Irradiated Mice.

Radioprotective Effect of Arbutin in Megavoltage Therapeutic X-irradiated Mice using Liver Enzymes Assessment

Background: Medical use of ionizing radiation has direct/indirect undesirable effects on normal tissues. In this study, the radioprotective effect of arbutin in megavoltage therapeutic x-irradiated mice was investigated using serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), and asparate amniotransferase (AST) activity measurements. Material and Methods: In this analytical...

In vivo radioprotective effects of recombinant human granulocyte colony-stimulating factor in lethally irradiated mice.

The purpose of this study was to investigate the in vivo radioprotective effects of recombinant human granulocyte colony stimulating factor (rhG-CSF) in lethally irradiated BALB/c mice. We initially analyzed the effects of increasing doses of rhG-CSF on survival of mice receiving 700 cGy (LD100/30) single dose total body irradiation (TBI). While 1 microgram/kg to 100 micrograms/kg doses of rhG-...

Effect of cimetidine and famotidine on survival of lethally gamma irradiated mice

Background: Currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. This study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated NMRI mice. Materials and Methods: Adult male NMRI mice in groups of 10 were exposed to various doses of gamm...

Reconstitution of Lethally Irradiated Adult

Effect of cimetidine and famotidine on survival of lethally gamma irradiated mice

There has been a major progress in the area of radioprotective agents since the early 1980s in terms of biological and mechanistic evaluation of the large number of naturally occurring or synthesized compounds. This information led to the development of a new generation of derivative compounds. The development of radio protective agents has been the subject of intense research in view of their ...